The PI3K Pathway in Cancer

The phosphoinositol 3 kinase (PI3K) pathway has been demonstrated to regulate many cellular processes, and when hyperactivated, to promote cancer. Learn more about the role of PI3K signaling in promoting the survival and proliferation of tumors.1-4

 

Acronyms: AKT = Ak strain transforming; mTOR = mammalian target of rapamycin; PI3K = phosphatidylinositol-3-kinase; PIP3 = phosphatidylinositol (3,4,5)-trisphosphate; PTEN = phosphatase and tensin homolog; RTK = receptor tyrosine kinase.

References: 1. Fayard E, Xue G, Parcellier A, Bozulic L, Hemmings BA. In: Rommel C, Vanhaesebroeck B, Vogt P, eds Phosphoinositide 3-kinase in Health and Disease. Current Topics in Microbiology and Immunology. Vol 346. Springer; 2010:31-56. doi:10.1007/82_2010_58. 2. Vivanco I, Sawyers LC. Nat Rev. 2002;2(7):489-501. doi:10.1038/nrc839. 3. Samuels Y, Velculescu VE. Cell Cycle. 2004;3(10):1221-1224. doi:10.4161/cc.3.10.1164. 4. Dienstmann R, Rodon J, Serra V, Tabernero J. Mol Cancer Ther. 2014;13(5):1021-1031. doi:10.1158/1535-7163.MCT-13-0639.