Expression of PSMA on Prostate Tumor Cells: Potential Utility for Phenotypic Precision Medicine
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer.1-3
PSMA is expressed in >80% of men with prostate cancer.1,4-6
High PSMA expression is correlated with poor outcomes.5,7,8
PSMA is expressed in certain nonprostate tissues, such as the kidneys, small intestine and salivary glands, at levels lower than in the prostate.9-11
PSMA may offer an opportunity for a phenotypic precision medicine approach in prostate cancer.12-14
PSMA is a transmembrane protein that is anchored in the cell membrane of prostate cancer epithelial cells. The binding of PSMA-targeted radioligands to PSMA may enable a phenotypic precision medicine approach, which is the ability to select patients based on a phenotypic biomarker, visualized using diagnostic imaging. This has the potential to be followed by investigational radioligand therapy, which targets the same phenotypic biomarker on prostate cancer cells.1,15,16
PSMA Expression Video
PSMA Expression Video
Acronyms: CT = computed tomography; Ga = gallium; MOA = mechanism of action; PET = positron emission tomography.
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Compound(s) are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established and there is no guarantee that they will become commercially available for the use(s) under investigation