Reimagining Medicine for Patients With Breast & Women's Cancer
The Treatment Gap in eBC
There is an urgent unmet medical need in early breast cancer (eBC). Learn about the unacceptable risk of recurrence and the limitations of currently available treatments to address the needs of patients with stage II & III HR+/HER2- eBC.
The Risk of Recurrence in HR+/HER2- Early Breast Cancer
Patients with HR+/HER2– early breast cancer carry a substantial risk of recurrence even with currently approved therapies.
Reimagining Medicine for Patients With Breast & Women's Cancer
Ribociclib Proposed Mechanism of Action in HR+/HER2− Early Breast Cancer
Investigational ribociclib is a CDK4/6 inhibitor with preferential selectivity for CDK4.
Intrinsic Subtypes in HR+/HER2-
Learn more about the prognostic and predictive value of intrinsic subtypes in HR+/HER2- advanced breast cancer and the capacity of these subtypes to subtype switch.
Compound(s) are either investigational or being studied for (a) new use(s). Efficacy and safety have not been established and there is no guarantee that they will become commercially available for the use(s) under investigation.
MOA data are based on in vitro/in vivo data.
aBC = advanced breast cancer; HER2- = human epidermal growth factor receptor 2 negative; HER2+ = human epidermal growth factor receptor 2 positive; HR+ = hormone receptor positive; PI3K = phosphoinositol 3 kinase; TNBC = triple-negative breast cancer.

Explore Clinical Trials
Explore Clinical Trials

HER2-enriched
Ribociclib vs Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype

TNBC
Ociperlimab in Combination With Tislelizumab and Chemotherapy in First-Line Treatment of Advanced Triple Negative Breast Cancer - AdvanTIG-211

HR+/HER2- EBC
Phase IIIb Study of Ribociclib and Endocrine Therapy in Early Breast Cancer (ADJUVANT WIDER)